Spravato(Esketamine) Online

What Is Esketamine (S-Ketamine)?

SPRAVATO™ (esketamine) is a form of ketamine that only has the S molecule. In 2019, the Food and Drug Administration (FDA) approved esketamine as a treatment for TRD, making it the first form of ketamine to receive FDA approval as a depression treatment. The exact method esketamine uses to relieve depression symptoms isn’t fully understood, but it appears that the S molecule in the medication binds to N-methyl-D-aspartate (NMDA) receptors in the brain.

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How Effective Is SPRAVATO™?

To get FDA approval, SPRAVATO™ underwent three short clinical trials and one longer trial. During the short-term trials, participants were either given SPRAVATO™ or a nasal spray placebo. Whether they received esketamine or the placebo, all trial participants were also given an antidepressant. They continued on the antidepressant throughout the trial.

In one trial, patients who received SPRAVATO™ nasal spray had statistically significant results compared to those who took the placebo. During the long-term trial, patients who had a stable response or who were in remission but continued treatment with SPRAVATO™ and an antidepressant had longer periods between symptom relapses compared to participants who received the placebo.

Upon approval of SPRAVATO™ (esketamine), Janssen, the company that produces it, issued a press release that stated that the medication could help reduce symptoms of depression within 24 hours when used with an oral antidepressant. Some patients in the clinical trial saw an improvement of their symptoms within four hours.

At the moment, SPRAVATO™ isn’t FDA-approved as a treatment to reduce suicidal thoughts or to prevent suicide, but some evidence suggests the medication can help reduce suicide ideation.

How to Qualify for SPRAVATO™ (esketamine)

To qualify for treatment with SPRAVATO™ (esketamine), you need to have been diagnosed with TRD. If you’ve previously tried at least two oral antidepressants and haven’t seen at least a 50% improvement in your mood or symptoms after six weeks, you might consider talking with your doctor about starting treatment with SPRAVATO™.

How Often Do You Take Esketamine?

The medication is effective in its alleviation of depressive symptoms, but the potential to abuse SPRAVATO™ (esketamine) exists. For now, the drug is only available under a Risk Evaluation and Mitigation Strategy (REMS) and only at certified treatment centers. A REMS protects the patient during treatment. Components of the REMS include:

• Enrolling patients in a registry.
• Providing patients with a guide that outlines the side effects and risks of the medication.
• Administering the medication in a supervised setting.

The initial treatment with SPRAVATO™ usually lasts for eight weeks. During the first four weeks, a patient visits the treatment center twice a week. During weeks five through eight, a patient visits once a week. After the eight-week mark, a patient might visit once or twice a week, based on their treatment provider’s recommendation.

At each appointment, the patient self-administers SPRAVATO™ using a nasal spray device. The nasal spray device contains 28 milligrams. Depending on their treatment provider’s recommendation, a patient will use two or three devices at each treatment.

The treatment provider will show the patient how to use the nasal spray. After the patient has performed the treatment, they will remain at the treatment center for at least two hours. During that time, the provider will monitor them for dissociation or sedation. Then, the provider will let the patient know when they can return home. Since SPRAVATO™ can cause sedation, an individual taking this medication must make arrangements to get home from the treatment center — they can’t drive themselves.

Side Effects of SPRAVATO™ (esketamine)

SPRAVATO™ can cause some side effects, the most common of which are sedation and disassociation. These symptoms can cause a patient to feel disconnected from their thoughts or feelings. Other possible symptoms include nausea and vomiting, reduced sensitivity and increased blood pressure. People with high blood pressure might have a higher risk of experiencing adverse cardiovascular events while taking esketamine.